Title
Oral treatment of avian lead intoxication with meso-2,3-dimercaptosuccinic acid
Author(s)
Hoogesteijn A.L., Raphael B.L., Calle P., Cook R., Kollias G.
Published
2003
Publisher
Journal of Zoo and Wildlife Medicine
Abstract
The efficacy of meso-dimercaptosuccinic acid (DMSA) (succimer) in treating avian lead intoxication was studied in a retrospective, nonrandomized, longitudinal study. Nineteen birds with moderate to high blood lead concentration and neurologic signs compatible with lead toxicity were treated with DMSA (30 mg/kg p.o., b.i.d.; n = 15) for a minimum of 7 days. In cases with severe neurologic signs, DMSA was supplemented with a single dose of edetate calcium disodium (<50.0 mg/kg of body weight i.m.; n = 4). Blood lead concentrations were measured two or more times (before and after treatment). Median blood lead concentration decreased (87%), neurologic signs were resolved, and there were no apparent adverse secondary effects.
Keywords
Aves; Galliformes; chelating agent; lead; succimer; animal; animal disease; article; bird; bird disease; blood; chemically induced disorder; lead poisoning; longitudinal study; oral drug administration; regression analysis; retrospective study; zoo animal; Administration, Oral; Animals; Animals, Zoo; Bird Diseases; Birds; Chelating Agents; Lead; Lead Poisoning; Longitudinal Studies; Regression Analysis; Retrospective Studies; Succimer
Access Full Text
A full-text copy of this article may be available. Please email the WCS Library to request.
![]()
Back
PUB12519